The success of e-commerce depends on strong infrastructure, powerful business processes, error-free codes in e-commerce site, and highly usable interfaces. However, the most important factor to achieve these goals is the quality of design process. The main objective of axiomatic design is to provide a scientific base for design process. Axioms are the propositions which are accepted as true. The design axioms are determined by the definition of common elements of good designs. There are four sets to systemize this interaction; customer, functional, physical and process definition sets. Customer Definition Set shows the expectations of the customer in manner of product, process, system or/and material. The customer needs are expressed as functional requirements and constraints in Functional Definition Set. The physical design parameters to correspond the functional requirements are defined in Physical Definition Set. And finally, the process characterized in manner of process variables is in Process Definition Set.